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LSD guide · Harms

Harms of LSD to the body and mind

Reviewed by: Dr. Mahmoud El-Sawy Last updated: September 28, 2026 9-minute read
The short answer

Most LSD harms are psychological and behavioral rather than physical: a bad trip full of terror and panic, risky decisions that can end in an accident or injury, and the possibility of triggering psychosis in people predisposed to it. Some visual disturbances may also return weeks or months after stopping, in what is known as hallucinogen persisting perception disorder. The risk rises when it is mixed with other substances.

  • The harm of a bad trip is possible from the very first time.
  • Accidents and risky behavior are the best-known cause of injuries and deaths linked to it.
  • People with a personal or family history of psychosis are the most vulnerable to harm.

What harms happen during the effects?

These harms appear during the long hours of the effect, and can affect anyone, even the first time:

  • The bad trip: intense terror, frightening hallucinations, and a sense of imminent death or losing one's mind.
  • Panic attacks: palpitations, shortness of breath, and a feeling of suffocation, with inability to calm down.
  • Delusions and persecution: believing others want to harm them, or strange ideas with no basis.
  • Temporary physical effects: a racing heart, raised blood pressure and temperature, sweating, tremor, nausea, and lack of sleep.
  • Impaired judgment: losing the ability to judge danger, such as distances, heights, and moving cars.

What is a bad trip and why is it dangerous?

A bad trip is a terrifying experience that can last hours, in which the person completely loses their sense of safety and cannot remind themselves that what they see is caused by a substance. Its likelihood is influenced by several factors, the most important being:

Mental state

Anxiety, sadness, or stress before use raises the chance of a bad trip.

Setting and company

Crowded or unfamiliar places, or feeling unsafe, increase the risk.

Unknown substance

An adulterated substance or one stronger than expected can make the experience more intense and longer.

Psychological predisposition

A previous psychiatric disorder or a family history of one.

A bad trip can leave an effect that lasts after it ends, such as anxiety, fear, panic attacks, and sleep disturbance for days or weeks, and some people need specialist psychological support to recover from it.

Does LSD cause psychosis or schizophrenia?

LSD can cause temporary psychotic symptoms during the effects. More dangerous, though, is that it can trigger a psychotic episode that continues after the effect wears off in people predisposed to it, especially those with a personal or family history of schizophrenia or bipolar disorder. In these cases the person may need long psychological and medication treatment.

This does not mean everyone who uses LSD will develop psychosis, but there is no way to know who is predisposed. That is why a family history of psychotic illness is a strong reason to avoid hallucinogens entirely. You will find more details on the page about drug-induced psychosis.

What is persistent perception disorder and recurring hallucinations?

Some people who used LSD experience, after stopping, a return of visual disturbances without new use, which is called a “flashback.” If these disturbances continue and cause distress or disrupt daily life, it is called hallucinogen persisting perception disorder (HPPD).

  • Halos around objects, and a trail of movement behind moving objects.
  • Afterimages that remain after looking at something, and changes in the intensity of colors.
  • A feeling of movement at the edge of vision, or changes in the size of objects.
  • May be triggered by stress, exhaustion, or entering a dark place.

This disorder is rare, but it is linked to LSD more than to other hallucinogens, and may occur even after a single experience. Some cases are brief and disappear, while others last a long time and need follow-up with a psychiatrist.

Does LSD harm the body's organs?

The available evidence does not suggest that LSD itself causes direct damage to the liver, kidneys, or brain the way other substances do. But there are real physical risks:

Physical risks linked to LSD
The riskWhy does it happen?
Injuries and accidentsImpaired judgment, hallucinations, and panic drive dangerous behavior.
Raised temperature and blood pressureA stimulating effect on the nervous system, increased by heat, exertion, and other substances.
SeizuresRare with LSD itself, and more likely with synthetic substances sold as LSD.
Heart strainA racing pulse and high blood pressure are a danger to people with heart disease.
Dehydration and exhaustionLong hours without enough sleep, food, or fluids.
Infographic: main harms of LSD: injuries and accidents, raised temperature and blood pressure, seizures, heart strain, dehydration and exhaustion
The main harms and complications of LSD

What is the risk of mixing LSD with other substances?

LSD is often taken with other substances at parties, which makes the effect less predictable and higher in risk:

Risks of mixing LSD
The mixThe main risk
With cannabisMay increase the intensity of hallucinations and anxiety and the chance of a bad trip.
With ecstasy or stimulantsStrain on the heart and raised temperature, and a doubled effect on mood.
With alcoholGreater impairment of judgment and balance, and a higher risk of accidents and vomiting.
With some psychiatric medicationsThe effect may change in unexpected ways, and no prescribed medication should be stopped or changed without the doctor.

LSD harms in teenagers and young people

The brain keeps developing until about the mid-twenties, especially the regions responsible for judgment and impulse control. A teenager who uses a powerful hallucinogen is more likely to engage in risky behavior and to be psychologically affected by a terrifying experience, and may see school performance drop and drift away from family. Early experience with hallucinogens also often comes as part of experimenting with several substances, which raises all the risks.

Social and legal harms

The harms of LSD are not limited to health; use can lead to legal problems because it is a banned substance, to problems at school and work after sleepless nights, and to strained family relationships because of unpredictable behavior. These harms often appear gradually without the person noticing them themselves.

Danger signs with LSD: call an ambulance (123) immediately

  • Severe agitation or violence that cannot be calmed, or an attempt to harm themselves or others
  • Dangerous behavior such as trying to jump from a height or going out into the road
  • Seizures or loss of consciousness
  • A very high body temperature with a rapid heartbeat or chest pain
  • Severe psychosis: complete detachment from reality or frightening delusions that do not end when the expected effect should have ended

Call an ambulance on 123, remove sharp objects and sources of danger, and stay with the person in a quiet place with low light and noise. Speak to them calmly and reassuringly, without restraining them by force except to prevent imminent injury. If they lose consciousness, place them on their side so they do not choke.

Call the ambulance 123
Frequently asked questions

Frequently asked questions about LSD harms to the body and mind

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Is trying LSD just once dangerous?

Yes, it can be; a bad trip, accidents, and even persistent perception disorder can happen the first time, and there is no way to predict who will experience them.

Does LSD damage brain cells?

There is no strong evidence that it causes direct damage to brain cells, but its effect on mental health and perception can be significant and lasting in some people.

Does LSD stay in the spine?

This is a common myth; LSD is not stored in the spine, and the return of hallucinations after stopping is linked to changes in how the brain processes images, not to leftover substance.

Does the return of hallucinations after LSD mean madness?

Not necessarily; persistent perception disorder differs from psychosis, since the person usually realizes that what they see is not real. But it deserves an assessment by a psychiatrist.

Does LSD affect pregnancy?

There are not enough studies to prove its safety, and any banned substance during pregnancy is a danger to mother and fetus, in addition to the risk of accidents while under its effects. It is best to speak openly with the doctor.

Is fear after an LSD experience normal?

Anxiety for days after a bad trip is common, but if it lasts more than two weeks or comes with panic attacks, strange thoughts, or severe sleep disturbance, it calls for seeing a psychiatrist.

Medical reviewDr. Mahmoud El-Sawy, Consultant Psychiatrist and Addiction Specialist

This page was written by the Eradah editorial team and reviewed by a specialist physician under the medical review policy. Last medically reviewed: September 28, 2026. The content is for education and does not replace consulting a doctor.

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