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Opium Guide · Harms

Harms of opium to the body and mind

Reviewed by: Dr. Mahmoud El-Sawy Last updated: September 28, 2026 9-minute read
The short answer

The harms of opium begin with drowsiness, constipation, nausea and suppressed breathing, and build up with continued use to include hormone deficiency, sleep disturbance and depression. The International Agency for Research on Cancer has classified opium use as carcinogenic to humans, linked to lung, larynx and bladder cancers. The most serious harm is death from overdose, especially when it is mixed with sedatives.

  • Variable strength and adulteration with substances such as lead add unpredictable dangers.
  • Older adults and people with lung and heart disease are more prone to its complications.
  • Many of the harms improve gradually after stopping and treatment.

What are the short-term harms of opium?

These harms appear within hours of use, and a person can experience them even the first few times:

  • Suppressed breathing and a slow heartbeat, which in an overdose can go as far as breathing stopping.
  • Severe drowsiness, slowed thinking and movement, and poor concentration.
  • Nausea, vomiting and dizziness, with a risk of choking on vomit if consciousness is lost.
  • Constipation, itchy skin, dry mouth and difficulty urinating.
  • Impaired judgment and decision-making, which raises the risk of accidents and injuries.

What are the long-term harms of opium to the body’s systems?

Opium’s harms to the body’s systems
SystemPossible harms
Respiratory systemSuppressed breathing, especially during sleep, worsening of chronic lung disease, and added harm when it is smoked.
Digestive systemSevere chronic constipation, bloating and cramps, loss of appetite and weight loss.
Hormonal systemLower sex hormones, sexual dysfunction in men, and menstrual irregularity in women.
Immune systemReduced resistance and repeated infections, with accompanying poor nutrition.
Bones and musclesA higher risk of falls and fractures because of drowsiness and dizziness, especially in older adults.
Urinary tractDifficulty urinating and urinary retention in some people who use it.
Infographic body map showing opium’s harms to the body’s organs: respiratory system, digestive system, hormonal system, immune system, bones and muscles, urinary tract
Opium’s harms to the body’s different systems

Does opium cause cancer?

In 2020, the International Agency for Research on Cancer of the World Health Organization classified opium use as Group 1: carcinogenic to humans, after reviewing the available scientific evidence. This means the evidence is sufficient to link it to cancer in humans.

Cancers linked to opium use according to IARC
Strength of evidenceCancer types
Sufficient evidenceLung cancer, laryngeal cancer, and bladder cancer.
Limited evidenceCancer of the esophagus, stomach, pancreas, and pharynx.

This risk is linked to the use of raw or minimally processed opium, and it does not mean that morphine medications used in hospitals cause cancer in the same way. The risk also rises with longer duration of use and is multiplied in smokers.

Why is adulterated opium an added danger?

Opium sold on the illicit market is not subject to any oversight, and it may be mixed with substances to increase its weight or change its appearance. Medical reviews from countries where opium is widespread have documented cases of lead poisoning among people who use it because of adulteration, and this poisoning can cause severe abdominal pain, anemia and nerve disorders.

What is the danger of mixing opium with sedatives and alcohol?

The World Health Organization considers using opioids together with alcohol or sedatives, such as benzodiazepines or other medications that suppress breathing, among the most important risk factors for death from overdose. It is common for opium to be mixed with sedatives, pregabalin or tramadol in search of a stronger effect, and this multiplies the suppression of breathing in ways that cannot be predicted.

Sedatives

Benzodiazepines with opium are among the most dangerous combinations for breathing.

Alcohol

It multiplies drowsiness and respiratory suppression and raises the risk of choking on vomit.

Other opioids

Mixing it with tramadol or codeine suddenly raises the total amount of opioids.

What are opium’s harms to the brain and mental health?

With repeated use, the brain adapts to the presence of opium, so its sense of natural pleasure weakens and it becomes more sensitive to stress. This shows up as:

Cognition

Poor memory and concentration, slowed thinking, and difficulty planning and making decisions.

Mood

Depression, anxiety, loss of enjoyment in usual activities, and mood swings between doses.

Sleep

Disrupted sleep cycles, and suppressed breathing during sleep in some people who use it.

Someone with a previous mental health condition such as depression or anxiety may get worse, and needs treatment that deals with both conditions together. Learn about dual diagnosis.

Why is opium more dangerous for older adults and people with chronic illness?

In communities where opium is traditionally used, those who use it are often older adults or people with chronic illnesses, believing it eases their pain. But their bodies are less able to clear it, their lungs and hearts are more sensitive to suppressed breathing, and they often take other medications that interact with it. This raises their risk of falls, confusion and overdose, and opium may hide the symptoms of serious illnesses so that diagnosis is delayed.

What are opium’s harms during pregnancy and to the fetus?

Use during pregnancy raises the risk of premature birth and low birth weight, and the baby may be born with neonatal withdrawal syndrome. Stopping suddenly during pregnancy without medical follow-up is not advised, because withdrawal itself can harm the fetus. It is best to go straight to a specialist doctor who will set a safe plan for the mother and the baby.

Why is opium more dangerous for teenagers and young people?

The brain keeps developing until roughly the mid-twenties, especially the regions responsible for impulse control and decision-making. That is why starting use at a young age raises the likelihood of addiction later and affects school performance, relationships and skill-building. Young people are also more likely to mix substances and experiment in groups, which raises their risk of overdose. And when use is familiar at home, children learn that it is normal, so they start early.

What are the social and financial harms of opium use?

  • A decline in the ability to work and be productive, despite the common belief that it helps with hard labor.
  • Financial strain on the family and debt as the amount needed grows.
  • Strained family relationships, and sometimes the pattern of use passing to children when it becomes familiar in the home.
  • Legal problems linked to possession and use.

Do opium’s harms go away after stopping?

Many of the harms improve gradually after stopping and treatment: sleep, appetite and bowel movement return, and hormones, mood and concentration improve within months. The cancer risk is tied to how long use lasted, and stopping early reduces further exposure. Any chronic damage to the lungs or elsewhere needs separate medical follow-up. The earlier treatment begins, the better the chances of recovery.

Signs of opium overdose: call an ambulance (123) immediately

  • Pupils that are extremely small, like pinpoints
  • Very slow, irregular or stopped breathing
  • Loss of consciousness, with no response to calling or touch
  • Blue lips and fingernails
  • Gurgling or unusual snoring sounds

Call an ambulance on 123, place the person on their side so they do not choke, and stay with them until help arrives. The medicine naloxone reverses the effect of an opioid overdose if given in time, and it is available in emergency departments.

Call the ambulance 123
Frequently asked questions

Frequently asked questions about opium’s harms to the body and mind

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What are the most serious harms of opium?

The most serious is death from overdose due to breathing stopping, especially with sedatives, followed by an increased risk of some cancers with long-term use.

Does opium cause lung cancer?

The International Agency for Research on Cancer has classified opium use as carcinogenic to humans, with sufficient evidence of a link to lung, larynx and bladder cancer.

Does opium harm the liver?

Opium’s main effects are on breathing, the digestive system and hormones, but adulterants, poor nutrition and mixing with other substances can add harm to the liver and elsewhere.

Does opium cause sexual dysfunction?

Yes. Repeated use lowers sex hormones and weakens desire and performance, contrary to the common belief, and this often improves after stopping.

Can opium contain lead?

Medical reviews have documented cases of lead poisoning among people who use adulterated opium, because its contents are not subject to any oversight.

Is opium less harmful than heroin?

It is often slower-acting and less potent, but it causes addiction and overdose, and adds the risk of cancer and adulteration, so it cannot be considered safe.

Does opium harm older adults more?

Yes, because their bodies clear it more slowly and are more sensitive to suppressed breathing, and they often take other medications that interact with it.

Medical reviewDr. Mahmoud El-Sawy, Consultant Psychiatrist and Addiction Specialist

This page was written by the Eradah editorial team and reviewed by a specialist physician under the medical review policy. Last medically reviewed: September 28, 2026. The content is for education and does not replace consulting a doctor.

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