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Heroin Guide · Harms

Harms of heroin to the body and mind

Reviewed by: Dr. Mahmoud El-Sawy Last updated: September 28, 2026 9-minute read
The short answer

The harms of heroin begin with the very first use, with slowed breathing, drowsiness and nausea, and they build up with continued use to affect the heart, lungs, liver, kidneys and brain, along with depression, anxiety and a risk of viral infection from injecting. Its most dangerous harm of all is death from overdose caused by breathing stopping.

  • Many of the physical harms improve gradually after stopping and starting treatment.
  • Using heroin during pregnancy exposes both mother and baby to serious complications.

Short-term harms of heroin

These harms appear within minutes to hours of use, and a person can experience them even the first few times:

  • Slowed breathing and a slow heartbeat, which can go as far as breathing stopping.
  • Severe drowsiness, confused thinking and slowed movement for hours.
  • Nausea and vomiting, with a risk of choking on vomit while unconscious.
  • Intense itching of the skin, dry mouth and a heavy feeling in the limbs.
  • Impaired decision-making, which raises the risk of accidents.

Long-term harms of heroin on the body

With repeated use over weeks and months, the harm builds up across the body's systems:

Harms of heroin on the body's systems
SystemPossible harms
Heart and blood vesselsInflammation of the lining of the heart and its valves, collapsed veins in people who inject, and blood clots.
Respiratory systemPneumonia, reduced lung function, and worsening asthma and allergies.
Liver and kidneysLiver disease, especially with viral infection, and reduced kidney function.
Digestive systemSevere chronic constipation, abdominal cramps, loss of appetite and weight loss.
SkinAbscesses and infections at injection sites, and visible marks on the arms.
Hormonal systemSexual dysfunction in men and menstrual irregularity in women.
Body map infographic of the harms of heroin to the brain, heart, lungs, liver, kidneys, digestive system, skin and hormones
Harms of heroin to the body's organs

Harms of heroin to the brain and mental health

Over time, heroin changes the structure and function of the brain, and research indicates that the white matter is affected in areas responsible for decision-making, regulating behavior and responding to stress. This shows up as:

Cognition

Poor concentration and memory, slowed thinking, and difficulty planning and controlling impulses.

Mood

Depression, anxiety and sharp mood swings, and loss of enjoyment in ordinary things.

Sleep

Insomnia and severe disruption of the sleep cycle, especially between doses.

These harms get worse if the person already has a mental health condition, which is known as dual diagnosis and needs treatment that addresses both conditions together.

How does a lack of oxygen harm the brain and body?

When heroin suppresses the breathing centers in the brain, less oxygen reaches the brain and the other organs, a condition called hypoxia. This can happen without ending in death, but it may leave lasting effects:

  • The brain: Lack of oxygen can cause a coma or permanent damage to brain cells, affecting memory, concentration and movement.
  • The lungs: Fluid can collect in the lungs, or pneumonia can develop from inhaling vomit while unconscious.
  • Muscles and kidneys: Lying unconscious in one position for hours can damage muscle tissue, which strains the kidneys and can lead to sudden kidney failure.

Harms of mixing heroin with other substances

Many people who use heroin mix it with other substances, knowingly or not, and this is among the most dangerous things that can happen:

Risks of mixing heroin
The mixThe main risk
Heroin + sedativesThe suppression of breathing is multiplied, and this is one of the best-known causes of death from overdose.
Heroin + alcoholDoubled suppression of breathing and consciousness, with a risk of choking on vomit.
Heroin + stimulantsSevere strain on the heart, and the stimulant masks the signs of suppressed breathing until its effect wears off.
Heroin laced with fentanylA sudden overdose from an amount the person believes is their usual dose.

Harms of injecting and sharing equipment

Repeated injecting also causes collapsed veins and infections of the skin and tissues, and bacteria can reach the blood and heart, causing life-threatening infections.

Do the harms differ depending on how the drug enters the body?

Heroin reaches the brain in every case, so the risk of addiction and overdose is shared, but each route adds its own harms:

Additional harms by route of use
MethodAdditional harms
InjectionsViral infections, collapsed veins, abscesses, and infections of the heart and blood.
Snorting through the noseDamage to the lining of the nose, repeated nosebleeds and sinus infections.
Inhaling vaporsLung irritation, chronic cough and worsening asthma, and rarely, serious damage to the brain's white matter.

The bottom line is that there is no "less harmful" route; the difference is in the type of harm, not in whether it exists.

Harms of heroin during pregnancy and to the baby

Use during pregnancy raises the risk of miscarriage, premature birth and low birth weight. The baby may be born with neonatal withdrawal syndrome, because its body became used to the drug in the womb. Stopping suddenly during pregnancy without medical supervision is not recommended, because withdrawal itself can harm the baby; the best course is to see a specialist doctor right away, who will set up a safe plan for mother and baby.

Harms of heroin in men and women

Heroin affects the sex and reproductive hormones, so different harms appear in each sex:

In men

Lower testosterone, reduced desire and erections, and disrupted sperm production.

In women

Irregular or absent periods, reduced fertility, and pregnancy complications.

These disturbances often improve gradually after stopping and starting treatment, with medical follow-up when needed.

Harms of heroin in teenagers

The brain continues to develop until roughly the mid-twenties, especially the regions responsible for planning and impulse control. This is why use in adolescence raises the risk of addiction and speeds up its onset, affects school performance and psychological and social development, and increases the likelihood of mental health conditions later. Early intervention at this stage makes a big difference to the chances of recovery.

How do the harms show up in daily life?

The harms of heroin do not appear all at once; they creep in gradually. It starts with waking up late and a slight drop in performance, then repeated absences, then debts and lying, then almost complete isolation in which the whole day revolves around getting the drug and avoiding withdrawal. Families often notice these changes before the person using admits them.

Social and financial harms

  • Losing a job or school place because of absence and poor performance.
  • Debt and financial pressure, which can go as far as theft or selling family belongings.
  • Breakdown of family relationships, loss of trust, and isolation from friends.
  • Legal problems linked to possession and use.

Do the harms of heroin go away after stopping?

Many of the harms improve gradually after stopping and starting treatment: sleep, appetite and digestive function return, and mood and concentration improve over months. Some harms, however, such as chronic viral infections or damaged heart valves, need separate treatment and follow-up. The earlier treatment begins, the greater the chance of full recovery.

Signs of a heroin overdose: call ambulance (123) immediately

  • Pupils that are extremely small, like pinpoints
  • Very slow, irregular or stopped breathing
  • Blue lips and fingernails
  • Loss of consciousness, with no response to calling or touch
  • Gurgling or unusual snoring sounds

Call ambulance (123), place the person on their side so they do not choke, and stay with them until help arrives. The drug naloxone reverses the effect of an overdose if given in time, and it is available in emergency departments.

Call the ambulance 123
Frequently asked questions

Frequently asked questions about the harms of heroin on the body and mind

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What are the most dangerous harms of heroin?

The most dangerous is death from overdose caused by breathing stopping, followed by chronic viral infections from injecting, heart infections and severe depression.

Does heroin cause permanent brain damage?

Long-term use may cause changes in the structure and function of the brain, but a large part of these improve with stopping, treatment and time, and this varies with how long and how heavily the person used.

Does heroin cause infertility?

It causes hormonal disturbances that can lead to sexual dysfunction and menstrual irregularity, and these often improve after stopping.

Is smoking heroin less harmful than injecting it?

The route into the body changes the type of some harms: injecting adds the risk of infection and collapsed veins, and smoking harms the lungs, but the risk of addiction and overdose exists with every route.

Does heroin affect the teeth?

It causes dry mouth, neglect of personal hygiene and poor nutrition, which raise the risk of tooth decay and gum disease in people who have used for long periods.

Does heroin cause heart disease?

It can cause inflammation of the lining of the heart and its valves, especially in people who inject, because of bacteria entering the blood, in addition to a slow heartbeat and depressed circulation.

Does an overdose leave harm if the person survives?

It can. A lack of oxygen while breathing is suppressed may damage the brain, lungs and kidneys, which is why a person who has had an overdose needs a medical assessment and treatment for addiction.

Medical reviewDr. Mahmoud El-Sawy, Consultant Psychiatrist and Addiction Specialist

This page was written by the Eradah editorial team and reviewed by a specialist physician under the medical review policy. Last medically reviewed: September 28, 2026. The content is for education and does not replace consulting a doctor.

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