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Drug family · Readily available depressants

Alcohol and inhalantsTheir types and harms, and why “easy to get” does not mean safe

Reviewed by: Dr. Mahmoud El-Sawy Last updated: September 28, 2026 11 min read
The short answer

Alcohol and inhalants are substances sold in shops or kept in the home, which is why many people think they are less risky than illegal drugs. But they slow down the nervous system just as sedatives do, and alcohol withdrawal can be life-threatening, while inhalants can cause sudden death even the first time they are used. Addiction to either is a treatable illness.

  • Alcohol is the most widely used mind-altering substance in the world.
  • Inhalants are most common among children and young teens because they are cheap and easy to get.
  • According to the World Health Organization, there is no “safe” level of alcohol when it comes to cancer risk.

What do we mean by alcohol and inhalants?

This family brings together two substances that differ in form and in who uses them most, but share two things: both are legally available for other purposes, and both depress the central nervous system.

Alcohol is the ethanol found in alcoholic drinks, one of the oldest and most widespread substances people have known. Inhalants are the fumes of household and industrial products sold for legitimate purposes, such as solvents, adhesives, sprays and gases, which are misused to get a quick, short-lived high.

Because getting these substances needs no dealer and no prescription, their danger is often underestimated within the family, until it shows up as an accident, a poisoning, a drop in school performance, or obvious addiction.

How do these substances affect the brain?

Both act as central nervous system depressants: they slow brain activity and weaken coordination, judgment and reaction time. Alcohol boosts the calming neurotransmitter GABA and weakens the stimulating neurotransmitter glutamate. With repeated use the brain adapts to its presence, and withdrawal appears when use stops.

At first

Relaxation, loosening up and less caution, then confusion and slowed movement and speech.

With larger amounts

Deeper depression of the nervous system that can lead to loss of consciousness, weak breathing and choking on vomit.

With repeated use

Tolerance and dependence, and gradual damage to the brain, nerves and liver.

Inhalants reach the brain within seconds through the lungs, and their effect is very brief, which pushes some people to repeat them many times in a row and raises the risk of oxygen deprivation and an irregular heart rhythm.

Types of alcohol and inhalants

Each substance in this family has a full guide and separate pages. Here is a short card for each:

Alcohol

Alcohol

Also known as: liquor

A nervous system depressant that damages the liver and brain, and severe withdrawal can cause seizures and delirium that require hospital care.

Classification
Nervous system depressant
Medical use
Not used medically
Addiction potential
High
Withdrawal
Very high

Main risk: cirrhosis and delirium tremens

Also known as: kolla, Silsion

Solvent fumes such as kolla (solvent glue) and gasoline, widely inhaled by teenagers, which can cause sudden cardiac arrest.

Classification
Volatile solvents
Medical use
Not used medically
Addiction potential
Moderate
Withdrawal
Moderate

Main risk: sudden cardiac arrest, even on the first use

The difference between alcohol and inhalants

A comparison of the two substances in the family
Point of comparisonAlcoholInhalants
Legal statusSold at licensed outlets with restrictionsLegal products made for other purposes
Most affected groupAdults and young peopleChildren and young teens
Speed and length of effectMinutes, lasting hoursSeconds, wearing off within minutes
Most serious dangerAcute poisoning and life-threatening withdrawalSudden death and oxygen deprivation
WithdrawalCan be dangerous and needs a hospitalOften mild, with cravings
Infographic comparing alcohol and inhalants on 5 points: legal status, most affected group, speed and length of effect, the most serious danger, withdrawal
The difference between alcohol and inhalants

Alcohol and inhalants in numbers

World Health Organization figures show the scale of a problem that is underestimated because the substance is easy to get. Alcohol alone is responsible for millions of deaths each year, a large share of them among young people:

2.6 milliondeaths worldwide caused by alcohol in 2019
400 millionpeople approximately have alcohol use disorders, about 7% of adults
209 millionpeople have alcohol dependence

Men bear the largest share of these deaths, and a notable proportion are concentrated in the 20 to 39 age group, the years of work and building a family. Figures for inhalants are hard to pin down because their use mostly happens out of sight, among street children and young teens, but their danger is not measured by the number of users; it lies in the possibility of death the very first time.

Source: World Health Organization alcohol fact sheet.

Risks shared across this family

  • Depressed breathing and consciousness, with the danger multiplied when they are mixed with sedatives or opioids.
  • Accidents, falls, drowning and burns while under the effect.
  • Damage to the brain and nerves with continued use, and poor memory and concentration.
  • Harm to the liver and heart, and with inhalants, harm to the kidneys and bone marrow.
  • Depression and anxiety, and a higher risk of self-harm during intoxication.
  • Falling behind at school or work, and family and legal problems.

The details of harm differ from one substance to another, so we have given separate pages to the harms of alcohol and the harms of kolla and inhalants.

Why do many teens start with these substances?

Some children and teens try inhalants or alcohol before any other substance, because they are cheap, close at hand and do not raise suspicion at first, and because curiosity, peer pressure and the wish to escape pressure at home or school are all strong factors at this age. The teenage brain is more sensitive to the harms of these substances and quicker to develop dependence.

Is withdrawal from these substances dangerous?

It differs a great deal between the two. Alcohol withdrawal in people who drink regularly can begin within hours of the last drink and progress from tremor and anxiety to seizures, and may reach delirium tremens, a medical emergency; that is why alcohol detox must be done under medical supervision. Withdrawal from inhalants is usually mild, such as irritability, insomnia, headache and cravings, but the real danger there is going back to use.

You will find the full details and the timeline on the page about alcohol withdrawal symptoms.

How is alcohol and inhalant addiction treated?

Treatment begins with a comprehensive medical and psychological assessment, then safe detox from the substance, followed by a rehabilitation program that addresses the causes of use and builds new skills for coping with stress. With alcohol there are approved medicines that help prevent relapse, chosen by the doctor; with inhalants, treatment relies on psychological, family and educational support and follow-up of any nerve damage.

  1. Step 1
    Assessment

    A medical and psychological examination, and assessment of any damage to the liver or nerves.

  2. Step 2
    Safe withdrawal

    Under medical supervision, and essential with alcohol because of the risk of seizures.

  3. Step 3
    Rehabilitation

    Individual, group and family psychotherapy, and treatment of any co-occurring disorder.

  4. Step 4
    Relapse prevention

    A plan for triggers, follow-up and support groups after discharge.

Infographic: How is alcohol and inhalant addiction treated? Assessment, then safe detox, then rehabilitation, then relapse prevention
How is alcohol and inhalant addiction treated?

Read more in alcohol addiction treatment and kolla and inhalant addiction treatment.

How can families protect their children?

  1. Talk with your children early about the fact that “easy to get” is not necessarily safe, in a calm tone without exaggerated scare tactics.
  2. Keep household chemical products out of children's reach, and watch for repeated disappearances.
  3. Set an example in handling stress without turning to any substance.
  4. Keep track of friends, places and changes at school without humiliating spying.
  5. Ask for help early; you can contact the Child Helpline 16000 if a child is in danger.

Danger signs with alcohol and inhalants: call ambulance (123) immediately

  • Loss of consciousness or difficulty waking the person
  • Slow, irregular or stopped breathing
  • Vomiting while semi-conscious
  • Seizures, whether during intoxication or within days of stopping alcohol
  • Chest pain or an obvious irregularity of the heartbeat
  • Cold, pale skin or bluish lips

Call ambulance on 123, place the person on their side so they do not choke on vomit, and do not leave them alone. With inhalants, move them to fresh air and do not frighten or chase them. Coffee, cold water and walking do not treat poisoning.

Call the ambulance 123
Frequently asked questions

Frequently asked questions about alcohol and inhalants

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Which is more dangerous, alcohol or inhalants?

Each carries a different danger. Inhalants can kill suddenly the first time and damage nerves quickly, while alcohol causes far more deaths worldwide because of how widespread it is, its chronic harms and its dangerous withdrawal. The more accurate comparison is that both need early intervention.

Is alcohol considered a drug?

Medically, alcohol is classed as a mind-altering substance and a nervous system depressant, and it causes dependence and addiction like drugs do, even though it is legally available in many countries.

Why are alcohol and inhalants in one family?

Because both depress the nervous system, both are legally available for other purposes, and their danger is often underestimated for that reason, although each is most used by a different group.

What is the most dangerous thing about kolla?

The most serious is sudden death from an irregular heart rhythm or suffocation, which can happen even the first time, along with permanent damage to the brain and nerves with repeated use.

Can alcohol withdrawal be fatal?

Yes. In people who are dependent on alcohol, withdrawal can cause seizures and delirium tremens, which are life-threatening, so it must be done under medical supervision.

At what age does inhalant use start?

It often starts at an early age, among children and young teens, because these products are cheap, easy to get and do not raise suspicion at first.

Is there treatment for alcohol addiction?

Yes. It includes safe detox under medical supervision, approved medicines to prevent relapse chosen by the doctor, psychological and family therapy, and long-term follow-up.

How do I know if my son is inhaling chemicals?

Signs include an unexplained chemical smell, stains on clothes or hands, a rash around the nose and mouth, dizziness, slurred speech and falling grades. If you suspect it, calmly seek specialist advice.

Is mixing alcohol with medicines dangerous?

Yes. Mixing alcohol with sedatives, sleeping pills or opioid painkillers multiplies the depression of breathing and consciousness and can be fatal.

Does alcohol really cause death?

Yes. The World Health Organization estimates that alcohol caused about 2.6 million deaths worldwide in 2019, from liver and heart disease, cancer, accidents and injuries.

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